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Acute Liver Injury due to Severe Epstein-Barr Virus Infection.

ABSTRACT: Epstein-Barr virus (EBV) is a widely dispersed herpesvirus, transferred through close personal contact between susceptible individuals and asymptomatic shedders of the virus. The liver is often affected, and involvement is usually subclinical and self-limited. However, immunocompromised patients and, more rarely, immunocompetent individuals can develop a severe and potentially fatal acute liver injury. To differentiate EBV hepatitis from other conditions, such as autoimmune hepatitis, lymphoproliferative disorders, and drug-induced liver injury, correlation with clinical history, laboratory findings, and histopathologic features is crucial. We report a unique case of a man who developed acute liver injury from a severe EBV infection.

SUBMITTER: Shah J

PROVIDER: S-EPMC7145184 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Acute Liver Injury due to Severe Epstein-Barr Virus Infection.

Shah Jamil J Lingiah Vivek V Pyrsopoulos Nikolaos N Galan Mark M

ACG case reports journal 20200224 2

Epstein-Barr virus (EBV) is a widely dispersed herpesvirus, transferred through close personal contact between susceptible individuals and asymptomatic shedders of the virus. The liver is often affected, and involvement is usually subclinical and self-limited. However, immunocompromised patients and, more rarely, immunocompetent individuals can develop a severe and potentially fatal acute liver injury. To differentiate EBV hepatitis from other conditions, such as autoimmune hepatitis, lymphoprol ...[more]

PMID: 32309513

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