Unknown

Dataset Information

0

Complementary Metal-Oxide-Semiconductor Potentiometric Field-Effect Transistor Array Platform Using Sensor Learning for Multi-ion Imaging.


ABSTRACT: This work describes an array of 1024 ion-sensitive field-effect transistors (ISFETs) using sensor-learning techniques to perform multi-ion imaging for concurrent detection of potassium, sodium, calcium, and hydrogen. Analyte-specific ionophore membranes are deposited on the surface of the ISFET array chip, yielding pixels with quasi-Nernstian sensitivity to K+, Na+, or Ca2+. Uncoated pixels display pH sensitivity from the standard Si3N4 passivation layer. The platform is then trained by inducing a change in single-ion concentration and measuring the responses of all pixels. Sensor learning relies on offline training algorithms including k-means clustering and density-based spatial clustering of applications with noise to yield membrane mapping and sensitivity of each pixel to target electrolytes. We demonstrate multi-ion imaging with an average error of 3.7% (K+), 4.6% (Na+), and 1.8% (pH) for each ion, respectively, while Ca2+ incurs a larger error of 24.2% and hence is included to demonstrate versatility. We validate the platform with a brain dialysate fluid sample and demonstrate reading by comparing with a gold-standard spectrometry technique.

SUBMITTER: Moser N 

PROVIDER: S-EPMC7145285 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Complementary Metal-Oxide-Semiconductor Potentiometric Field-Effect Transistor Array Platform Using Sensor Learning for Multi-ion Imaging.

Moser Nicolas N   Leong Chi Leng CL   Hu Yuanqi Y   Cicatiello Chiara C   Gowers Sally S   Boutelle Martyn M   Georgiou Pantelis P  

Analytical chemistry 20200320 7


This work describes an array of 1024 ion-sensitive field-effect transistors (ISFETs) using sensor-learning techniques to perform multi-ion imaging for concurrent detection of potassium, sodium, calcium, and hydrogen. Analyte-specific ionophore membranes are deposited on the surface of the ISFET array chip, yielding pixels with quasi-Nernstian sensitivity to K<sup>+</sup>, Na<sup>+</sup>, or Ca<sup>2+</sup>. Uncoated pixels display pH sensitivity from the standard Si<sub>3</sub>N<sub>4</sub> pass  ...[more]

Similar Datasets

| S-EPMC5424868 | biostudies-literature
| S-EPMC5974700 | biostudies-literature
| S-EPMC2735726 | biostudies-literature
| S-EPMC6630652 | biostudies-literature
| S-EPMC7601498 | biostudies-literature
| S-EPMC4936408 | biostudies-literature
| S-EPMC7813837 | biostudies-literature
| S-EPMC6648902 | biostudies-literature
| S-EPMC7147468 | biostudies-literature
| S-EPMC8173557 | biostudies-literature