Ontology highlight
ABSTRACT:
SUBMITTER: Tong XY
PROVIDER: S-EPMC7145388 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Tong Xin-Yu XY Liao Xuan X Gao Min M Lv Bo-Min BM Chen Xiao-Hui XH Chu Xin-Yi XY Zhang Qing-Ye QY Zhang Hong-Yu HY
Frontiers in molecular biosciences 20200331
Recent studies have revealed the important role of NUDT5 in estrogen signaling and breast cancer, but research on the corresponding targeted therapy has just started. Drug repositioning strategy can effectively reduce the time and economic resources spent on drug discovery. To find novel inhibitors of NUDT5, we investigated the previously identified connectivity map-based drug association models and found eighteen FDA approved drugs as candidates. The molecular docking and molecular dynamic simu ...[more]