Nanobubble Mediated Gene Delivery in Conjunction With a Hand-Held Ultrasound Scanner.
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ABSTRACT:
SUBMITTER: Kida H
PROVIDER: S-EPMC7145407 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Nanobubble Mediated Gene Delivery in Conjunction With a Hand-Held Ultrasound Scanner.
Kida Hiroshi H Nishimura Koyo K Ogawa Koki K Watanabe Akiko A Feril Loreto B LB Irie Yutaka Y Endo Hitomi H Kawakami Shigeru S Tachibana Katsuro K
Frontiers in pharmacology 20200401
Recent research has revealed that nanobubbles (NBs) can be an effective tool for gene transfection in conjunction with therapeutic ultrasound (US). However, an approach to apply commercially available hand-held diagnostic US scanners for this purpose has not been evaluated as of now. In the present study, we first compared <i>in vitro</i>, the efficiency of gene transfer (pCMV-Luciferase) with lipid-based and albumin-based NBs irradiated by therapeutic US (1MHz, 5.0 W/cm<sup>2</sup>) in oral squ ...[more]
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