PhaSePro: the database of proteins driving liquid-liquid phase separation.

ABSTRACT: Membraneless organelles (MOs) are dynamic liquid condensates that host a variety of specific cellular processes, such as ribosome biogenesis or RNA degradation. MOs form through liquid-liquid phase separation (LLPS), a process that relies on multivalent weak interactions of the constituent proteins and other macromolecules. Since the first discoveries of certain proteins being able to drive LLPS, it emerged as a general mechanism for the effective organization of cellular space that is exploited in all kingdoms of life. While numerous experimental studies report novel cases, the computational identification of LLPS drivers is lagging behind, and many open questions remain about the sequence determinants, composition, regulation and biological relevance of the resulting condensates. Our lim

SUBMITTER: Meszaros B 

PROVIDER: S-EPMC7145634 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature