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Non-Coding RNAs in CD4+ T Cells: New Insights Into the Pathogenesis of Systemic Lupus Erythematosus.


ABSTRACT: Non-coding RNAs (ncRNAs) are indispensable for CD4+ T cell differentiation and functions. By directly or indirectly regulating immune gene expression, ncRNAs give flexible instructions to guide the biological processes of CD4+ T cells and play a vital role in maintaining immune homeostasis. However, the dysfunction of ncRNAs alters the gene expression profiles, disturbs the normal biological processes of CD4+ T cells, and leads to the functional changes of CD4+ T cells, which is an underlying cause of systemic lupus erythematosus (SLE). In this review, we focus on the recent advances in the roles of ncRNAs in CD4+ T cell functions and differentiation, as well as their potential applications in the diagnosis and treatment of SLE.

SUBMITTER: Gao X 

PROVIDER: S-EPMC7145980 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Non-Coding RNAs in CD4<sup>+</sup> T Cells: New Insights Into the Pathogenesis of Systemic Lupus Erythematosus.

Gao Xiaofei X   Liu Limin L   Min Xiaoli X   Jia Sujie S   Zhao Ming M  

Frontiers in immunology 20200403


Non-coding RNAs (ncRNAs) are indispensable for CD4<sup>+</sup> T cell differentiation and functions. By directly or indirectly regulating immune gene expression, ncRNAs give flexible instructions to guide the biological processes of CD4<sup>+</sup> T cells and play a vital role in maintaining immune homeostasis. However, the dysfunction of ncRNAs alters the gene expression profiles, disturbs the normal biological processes of CD4<sup>+</sup> T cells, and leads to the functional changes of CD4<su  ...[more]

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