Sensing Performance Investigations on Two-Photon Fluorescent Probes for Detecting β-Amyloid in Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is one of the most common forms of senile disease. In recent years, the incidence of AD has been increasing significantly with the acceleration of the aging process of the global population. However, current clinical drugs can only alleviate the symptoms of AD patients without healing the disease fundamentally. Therefore, it is of great significance to develop an effective small molecule diagnostic reagent for the early diagnosis of AD. In this paper, we employ an integrated approach, including molecular docking simulation and quantum mechanics/molecular mechanics calculation, to investigate the sensing performance of a series of donor-acceptor structural probes for the marker protein of AD (β-amyloid). Results show that the probes display evident fluorescen

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7146205 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature