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Angiotensin Converting Enzyme (ACE): A Marker for Personalized Feedback on Dieting.


ABSTRACT: Angiotensin Converting Enzyme (ACE) expression and activity is associated with obesity. ACE is a circulating factor that predicts sustained weight loss over a time frame of months. Here, we evaluate whether ACE might also be an early marker (over a 24-hour period) for weight loss. 32 participants (78% females; BMI 28.47 ± 4.87kg/m2) followed a 1200KCal diet with an optional daily (<250KCal) snack and were asked to use an in-house generated health platform to provide recordings of food intake, physical activity and urine collection time and volume. Following a day of dieting, ACE levels in urine negatively correlated with weight loss (p = 0.015 ). This reduction in ACE levels was significantly more robust in individuals with a BMI > 25 (p = 0.0025 ). This study demonstrated that ACE levels correlate with BMI and weight loss as early as after 1 day of dieting, and thus ACE could be a potential early "biofeedback" marker for weight loss and diet efficiency.

SUBMITTER: Tejpal S 

PROVIDER: S-EPMC7146434 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Angiotensin Converting Enzyme (ACE): A Marker for Personalized Feedback on Dieting.

Tejpal Shilpa S   Sanghera Narinder N   Manoharan Vijayalaxmi V   Planas-Iglesias Joan J   Bastie Claire C CC   Klein-Seetharaman Judith J  

Nutrients 20200228 3


Angiotensin Converting Enzyme (ACE) expression and activity is associated with obesity. ACE is a circulating factor that predicts sustained weight loss over a time frame of months. Here, we evaluate whether ACE might also be an early marker (over a 24-hour period) for weight loss. 32 participants (78% females; BMI 28.47 ± 4.87kg/m2) followed a 1200KCal diet with an optional daily (<250KCal) snack and were asked to use an in-house generated health platform to provide recordings of food intake, ph  ...[more]

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