Cognitive fatigue in relation to depressive symptoms after treatment for childhood cancer.

ABSTRACT: BACKGROUND:Cognitive fatigue after childhood cancer is frequently overlooked despite guidelines recommending follow-up, and might be mistaken for depression due to overlapping symptoms. Our objectives were: 1) to examine ratings of fatigue in survivors of paediatric brain tumours (BT) and acute lymphoblastic leukaemia (ALL) compared to healthy controls, 2) to examine the relationship between symptoms of depression and cognitive fatigue, and 3) to evaluate parent-child concordance in ratings of cognitive fatigue. METHODS:Survivors of BT (n?=?30), survivors of ALL (n?=?30), and healthy controls (n?=?60) aged 8-18?years completed the Pediatric Quality of Life Multidimensional Fatigue Scale and the Beck Youth Inventories. Associations between cognitive fatigue, diagnosis and depression were assessed with general linear modelling. Group differences were analysed using the Kruskal-Wallis test. Parent-child concordance was investigated with internal consistency reliability. RESULTS:Cognitive fatigue was prevalent in 70% of survivors of BT survivors and in 30% of survivors of ALL. Diagnosis was the main predictor of cognitive fatigue (p?

SUBMITTER: Irestorm E 

PROVIDER: S-EPMC7146960 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature