Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study.

ABSTRACT:

Background

Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. We evaluated the association between exposure to single and multiple metals, including arsenic, lead, and manganese, to humoral immunity as measured by antibody concentrations to diphtheria and tetanus toxoid among vaccinated Bangladeshi children. Additionally, we examined if this association was potentially mediated by nutritional status.

Methods

Antibody concentrations to diphtheria and tetanus were measured in children's serum at age 5 (n = 502). Household drinking water was sampled to quantify arsenic (W-As) and manganese (W-Mn), whereas lead was measured in blood (B-Pb). Exposure samples were taken during pregnancy, toddlerhood, and early childhood. Multiple

SUBMITTER: Welch BM 

PROVIDER: S-EPMC7146972 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature