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RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China.


ABSTRACT: BACKGROUND:RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population. METHODS:We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Four RIPK1 genetic variants (rs6907943, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under Binary logistic regression models. False discovery rate (FDR) was used to improve the results reliability. RESULTS:The results showed rs2077681 was significantly associated with cervical cancer risk under various genetic models (codominant: OR?=?3.14, 95% CI?=?1.40-7.07, p?=?0.006, FDR-p?=?0.018; recessive: OR?=?3.20, 95% CI?=?1.43-7.16, p?=?0.005, FDR-0.018). The stratified analysis indicated that the relationships of rs6907946, rs9503400 and rs17548629 with cervical cancer risk were statistically significant in the subgroup of clinical stage (p?

SUBMITTER: Tuoheti Z 

PROVIDER: S-EPMC7146988 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China.

Tuoheti Zulipiyamu Z   Han Lili L   Husaiyin Sulaiya S   Liu Xiaoxi X   Ma Chunhua C   Niyazi Mayinuer M  

BMC cancer 20200409 1


<h4>Background</h4>RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population.<h4>Methods</h4>We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Four RIPK1 genetic variants (rs6907943, rs2077681, rs9503400 and rs175486  ...[more]

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