Ontology highlight
ABSTRACT:
SUBMITTER: Eremina NV
PROVIDER: S-EPMC7147088 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Eremina Natalia V NV Kazey Vasily I VI Mishugin Sergey V SV Leonenkov Roman V RV Pushkar Dmitry Y DY Mett Vadim L VL Gudkov Andrei V AV
Oncotarget 20200407 14
Toll-like receptor 5 (TLR5) controls endogenous immune responses to pathogens and is a promising target for pharmacological stimulation of anti-tumor immunity. Mobilan is an innovative gene therapy agent consisting of a non-replicating bicistronic adenovirus directing constitutive expression of human Toll-like receptor 5 (TLR5) and the secreted flagellin-based TLR5 agonist, 502s. In mice, Mobilan injection into prostate tumors resulted in autocrine TLR5 signaling, immune system activation, and s ...[more]