Ontology highlight
ABSTRACT:
SUBMITTER: Dziengelewski C
PROVIDER: S-EPMC7147092 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Dziengelewski Claire C Rodrigue Marc-Antoine MA Caillier Alexia A Jacquet Kévin K Boulanger Marie-Chloé MC Bergeman Jonathan J Fuchs Margit M Lambert Herman H Laprise Patrick P Richard Darren E DE Bordeleau François F Huot Marc-Étienne MÉ Lavoie Josée N JN
The Journal of cell biology 20200401 4
The tumor cell-selective killing activity of the adenovirus type 2 early region 4 ORF4 (E4orf4) protein is poorly defined at the molecular level. Here, we show that the tumoricidal effect of E4orf4 is typified by changes in nuclear dynamics that depend on its interaction with the polarity protein Par3 and actomyosin contractility. Mechanistically, E4orf4 induced a high incidence of nuclear bleb formation and repetitive nuclear ruptures, which promoted nuclear efflux of E4orf4 and loss of nuclear ...[more]