Ontology highlight
ABSTRACT:
SUBMITTER: Roy Chowdhury S
PROVIDER: S-EPMC7147096 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Roy Chowdhury Sudeshna S Bhattacharjee Chumki C Casler Jason C JC Jain Bhawik Kumar BK Glick Benjamin S BS Bhattacharyya Dibyendu D
The Journal of cell biology 20200401 4
COPI vesicles mediate Golgi-to-ER recycling, but COPI vesicle arrival sites at the ER have been poorly defined. We explored this issue using the yeast Pichia pastoris. ER arrival sites (ERAS) can be visualized by labeling COPI vesicle tethers such as Tip20. Our results place ERAS at the periphery of COPII-labeled ER export sites (ERES). The dynamics of ERES and ERAS are indistinguishable, indicating that these structures are tightly coupled. Displacement or degradation of Tip20 does not alter ER ...[more]