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Mycosis Fungoides and Sezary Syndrome: An Update.

ABSTRACT: Cutaneous T-cell lymphomas are a heterogeneous collection of non-Hodgkin lymphomas that arise from skin-tropic memory T lymphocytes. Among them, mycosis fungoides (MF) and Sézary syndrome (SS) are the most common malignancies. Diagnosis requires the combination of clinical, pathologic, and molecular features. Significant advances have been made in understanding the genetic and epigenetic aberrations in SS and to some extent in MF. Several prognostic factors have been identified. The goal of treatment is to minimize morbidity and limit disease progression. However, hematopoietic stem cell transplantation, considered for patients with advanced stages, is the only therapy with curative intent.

SUBMITTER: Larocca C

PROVIDER: S-EPMC7147244 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Mycosis Fungoides and Sézary Syndrome: An Update.

Larocca Cecilia C Kupper Thomas T

Hematology/oncology clinics of North America 20190201 1

Cutaneous T-cell lymphomas are a heterogeneous collection of non-Hodgkin lymphomas that arise from skin-tropic memory T lymphocytes. Among them, mycosis fungoides (MF) and Sézary syndrome (SS) are the most common malignancies. Diagnosis requires the combination of clinical, pathologic, and molecular features. Significant advances have been made in understanding the genetic and epigenetic aberrations in SS and to some extent in MF. Several prognostic factors have been identified. The goal of trea ...[more]

PMID: 30497668

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