Ontology highlight
ABSTRACT:
SUBMITTER: Inglis AJ
PROVIDER: S-EPMC7147533 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Inglis Alison J AJ Page Katharine R KR Guna Alina A Voorhees Rebecca M RM
Cell reports 20200301 11
A large proportion of membrane proteins must be assembled into oligomeric complexes for function. How this process occurs is poorly understood, but it is clear that complex assembly must be tightly regulated to avoid accumulation of orphan subunits with potential cytotoxic effects. We interrogated assembly in mammalian cells by using the WRB/CAML complex, an essential insertase for tail-anchored proteins in the endoplasmic reticulum (ER), as a model system. Our data suggest that the stability of ...[more]