S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE-/- mice.
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ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC7147689 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE<sup>-/-</sup> mice.
Park Jooneon J Gao Huiyun H Wang Yunmei Y Hu He H Simon Daniel I DI Steinmetz Nicole F NF
Journal of materials chemistry. B 20190213 11
We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE<sup>-/-</sup> mice. ...[more]
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