Ontology highlight
ABSTRACT:
SUBMITTER: Guo X
PROVIDER: S-EPMC7147832 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Guo Xiaoyan X Aviles Giovanni G Liu Yi Y Tian Ruilin R Unger Bret A BA Lin Yu-Hsiu T YT Wiita Arun P AP Xu Ke K Correia M Almira MA Kampmann Martin M
Nature 20200304 7799
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the induction of the transcription factor ATF4<sup>1-3</sup>. However, how mitochondrial stress is relayed to ATF4 is unknown. Here we show that HRI is the eIF2α kinase that is necessary and sufficient for this relay. In a genome-wide CRISPR interference screen, we identified factors upstream of HRI: OMA1, a mitochon ...[more]