Ontology highlight
ABSTRACT:
SUBMITTER: Colas C
PROVIDER: S-EPMC7148354 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Colas Claire C Banci Giulia G Martini Riccardo R Ecker Gerhard F GF
Scientific reports 20200410 1
Creatine is a crucial metabolite that plays a fundamental role in ATP homeostasis in tissues with high-energy demands. The creatine transporter (CreaT, SLC6A8) belongs to the solute carrier 6 (SLC6) transporters family, and more particularly to the GABA transporters (GATs) subfamily. Understanding the molecular determinants of specificity within the SLC6 transporters in general, and the GATs in particular is very challenging due to the high similarity of these proteins. In the study presented he ...[more]