Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC7148483 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Jiang Yanchao Y Zhang Ting T Kusumanchi Praveen P Han Sen S Yang Zhihong Z Liangpunsakul Suthat S
Biomedicines 20200304 3
Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase<b>.</b> Acetaldehyde can form adducts which can interfere with cellular function, leading to alcohol-induced liver injury. The variants of alcohol metabolizing genes encode enzymes with varied kinetic properties and result in the different rate of alcohol eliminatio ...[more]