Ontology highlight
ABSTRACT:
SUBMITTER: Ontiveros RJ
PROVIDER: S-EPMC7149399 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Ontiveros R Jordan RJ Shen Hui H Stoute Julian J Yanas Amber A Cui Yixiao Y Zhang Yuyu Y Liu Kathy Fange KF
Proceedings of the National Academy of Sciences of the United States of America 20200325 14
The posttranscriptional modification of messenger RNA (mRNA) and transfer RNA (tRNA) provides an additional layer of regulatory complexity during gene expression. Here, we show that a tRNA methyltransferase, TRMT10A, interacts with an mRNA demethylase FTO (ALKBH9), both in vitro and inside cells. TRMT10A installs <i>N</i><sup>1</sup>-methylguanosine (m<sup>1</sup>G) in tRNA, and FTO performs demethylation on <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) and <i>N</i><sup>6</sup>,2'-<i>O</ ...[more]