Unknown

Dataset Information

0

Innate Humoral Defense Factors


ABSTRACT: Although innate immunity came into the research spotlight in the late 1990s when its instructive role in the adaptive immune response was recognized, innate humoral defense factors have a much older history. The exocrine secretions of the body contain a plethora of distinct soluble factors (lysozyme, lactoferrin, peroxidases, proline-rich proteins, histatins, etc.) that protect the body from mucosal microbial pathogens. More recent studies have established that the humoral arm of innate immunity contains a heterogeneous group of pattern-recognition molecules (e.g., pentraxins, collectins, and ficolins), which perform diverse host-defense functions, such as agglutination and neutralization, opsonization, control of inflammation, and complement activation and regulation. These pattern-recognition molecules, which act as functional predecessors of antibodies (“ante-antibodies”), and the classic soluble innate defense factors form an integrated system with complementary specificity, action, and tissue distribution, and they are the subject of this chapter.

SUBMITTER: Hajishengallis G 

PROVIDER: S-EPMC7149745 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7149504 | biostudies-literature
| S-EPMC1865766 | biostudies-literature
| S-EPMC2881842 | biostudies-literature
| S-EPMC7235825 | biostudies-literature
2019-07-01 | E-MTAB-7741 | biostudies-arrayexpress
| S-EPMC6500135 | biostudies-literature
| S-EPMC3461926 | biostudies-literature
| S-EPMC8253364 | biostudies-literature
| S-EPMC2707954 | biostudies-other
| S-EPMC3280516 | biostudies-literature