Unknown

Dataset Information

0

Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis.


ABSTRACT: BACKGROUND:Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of this study was to explore the efficacy and safety of the intra-articular injection of PRP combined with HA compared with the intra-articular injection of PRP or HA alone in the treatment of KOA. METHODS:The PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure (CNKI) databases were searched from inception to December 2019. Randomized controlled trials and cohort studies of PRP combined with HA for KOA were included. Two orthopaedic surgeons conducted the literature retrieval and extracted the data. Outcome indicators included the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Lequesne Index, the visual analogue scale (VAS) for pain, and adverse events (AEs). Review Manager 5.3 was used to calculate the relative risk (RR) or standardized mean difference (SMD) of the pooled data. STATA 14.0 was used for quantitative publication bias evaluation. RESULTS:Seven studies (5 randomized controlled trials, 2 cohort studies) with a total of 941 patients were included. In the VAS comparison after 6?months of follow-up, PRP combined with HA was more likely to reduce knee pain than PRP alone (SMD: -?0.31; 95% confidence interval (CI): -?0.55 to -?0.06; P?=?0.01??0.05). CONCLUSIONS:Compared with intra-articular injection of PRP alone, that of PRP combined with HA can improve the WOMAC Function Scores, WOMAC Total Score, 6-month follow-up VAS ratings, and Lequesne Index scores. However, in terms of the incidence of AEs, PRP combined with HA is not significantly different from PRP or HA alone.

SUBMITTER: Zhao J 

PROVIDER: S-EPMC7149899 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis.

Zhao Jinlong J   Huang Hetao H   Liang Guihong G   Zeng Ling-Feng LF   Yang Weiyi W   Liu Jun J  

BMC musculoskeletal disorders 20200411 1


<h4>Background</h4>Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of this study was to explore the efficacy and safety of the intra-articular injection of PRP combined with HA compared with the intra-articular injection of PRP or HA alone in the treatment of KOA.<h4>Methods</h4>The PubMed, Cochrane Library, EMBASE and China National Knowled  ...[more]

Similar Datasets

| S-EPMC6824920 | biostudies-literature
| S-EPMC7889864 | biostudies-literature
| S-EPMC7488405 | biostudies-literature
| S-EPMC8010808 | biostudies-literature
| S-EPMC7794411 | biostudies-literature
| S-EPMC8623697 | biostudies-literature
| S-EPMC9415551 | biostudies-literature
| S-EPMC10783230 | biostudies-literature
| S-EPMC10508439 | biostudies-literature
| S-EPMC4314556 | biostudies-other