Dataset Information

Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.

ABSTRACT:

Background

Loss of function of triggering receptor expressed on myeloid cell 2 (TREM2), a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer's disease (AD). Whether TREM2 levels are pathologically altered during the preclinical phase, and whether cerebrospinal fluid (CSF) soluble TREM2 protein (sTREM2) has a relationship with major pathological processes including Aβ and tau deposition are still unclear.

Methods

According to the NIA-AA criteria, 659 cognitively normal participants from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) cohort were divided into four groups, stage 0 (normal Aβ_1-42, T-tau and P-tau), stage 1 (low Aβ_1-42, normal T-tau and P-tau), stage 2 (low Aβ_1-42 and high T-tau or P-tau), and suspected non-AD pathology (SNAP) (normal Aβ_1-42 and high T-tau or P-tau), to examine changes of CSF sTREM2 in the preclinical AD. Biomarker cut-off was based on the assumption that one-third of adults with normal cognition have AD pathology.

Results

The level of CSF sTREM2 in the stage 1 decreased compared with the stage 0 (P < 0.001), and then increased in the stage 2 (P = 0.008). SNAP individuals also had significantly increased CSF sTREM2 (P < 0.001). Results of multiple linear regressions also showed positive correlations of CSF sTREM2 with Aβ_1-42 (β = 0.192, P < 0.001), T-tau (β = 0.215, P < 0.001) and P-tau (β = 0.123, P < 0.001).

Conclusion

CSF sTREM2 levels are dynamic in preclinical AD. Aβ pathology is associated with a decrease in CSF sTREM2 in the absence of tau deposition and neurodegeneration. However, tau pathology and neurodegeneration are associated with an increase in CSF sTREM2.

SUBMITTER: Ma LZ

PROVIDER: S-EPMC7149923 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Publications

Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.

Ma Ling-Zhi LZ Tan Lan L Bi Yan-Lin YL Shen Xue-Ning XN Xu Wei W Ma Ya-Hui YH Li Hong-Qi HQ Dong Qiang Q Yu Jin-Tai JT

Molecular neurodegeneration 20200410 1

<h4>Background</h4>Loss of function of triggering receptor expressed on myeloid cell 2 (TREM2), a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer's disease (AD). Whether TREM2 levels are pathologically altered during the preclinical phase, and whether cerebrospinal fluid (CSF) soluble TREM2 protein (sTREM2) has a relationship with major pathological processes including Aβ and tau deposition are still unclear.<h4>Methods</h4>According to t ...[more]

PMID: 32276587

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Dataset Information

Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.

Background

Methods

Results

Conclusion

Publications

Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.

Similar Datasets

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