Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC7150427 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yang Hua H Qing Keyun K Keeler Geoffrey D GD Yin Ling L Mietzsch Mario M Ling Chen C Hoffman Brad E BE Agbandje-McKenna Mavis M Tan Mengqun M Wang Wei W Srivastava Arun A
Molecular therapy. Nucleic acids 20200329
We have reported that of the 10 most commonly used adeno-associated virus (AAV) serotype vectors, AAV6 is the most efficient in transducing primary human hematopoietic stem cells (HSCs) in vitro, as well as in vivo. More recently, polyvinyl alcohol (PVA), was reported to be a superior replacement for human serum albumin (HSA) for ex vivo expansion of HSCs. Since HSA has been shown to increase the transduction efficiency of AAV serotype vectors, we evaluated whether PVA could also enhance the tra ...[more]