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Long non-coding RNAs in immune regulation and their potential as therapeutic targets.

ABSTRACT: Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immunological disorders and further discuss RNA-targeting approaches that could be potentially exploited to manipulate lncRNA function as a clinical intervention.

SUBMITTER: Uthaya Kumar DB

PROVIDER: S-EPMC7150622 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Long non-coding RNAs in immune regulation and their potential as therapeutic targets.

Uthaya Kumar Dinesh Babu DB Williams Adam A

International immunopharmacology 20200212

Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immun ...[more]

PMID: 32058929

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