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Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial.


ABSTRACT: The essential trace element zinc maintains liver functions. Liver diseases can alter overall zinc concentrations, and hypozincemia is associated with various hepatic pathologies. Modulating systemic zinc through dietary supplementation is potentially useful for liver diseases. We evaluated the usefulness of zinc (NPC-02; acetate formulation) supplementation. We conducted two NPC-02 studies on zinc-deficient patients (serum zinc

SUBMITTER: Katayama K 

PROVIDER: S-EPMC7150658 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial.

Katayama Kazuhiro K   Hosui Atsushi A   Sakai Yoshiyuki Y   Itou Minoru M   Matsuzaki Yasushi Y   Takamori Yoriyuki Y   Hosho Keiko K   Tsuru Tomomi T   Takikawa Yasuhiro Y   Michitaka Kojiro K   Ogawa Eishin E   Miyoshi Yoko Y   Ito Toshifumi T   Ida Shinobu S   Hamada Izumi I   Miyoshi Katsunori K   Kodama Hiroko H   Takehara Tetsuo T  

Biological trace element research 20190807 1


The essential trace element zinc maintains liver functions. Liver diseases can alter overall zinc concentrations, and hypozincemia is associated with various hepatic pathologies. Modulating systemic zinc through dietary supplementation is potentially useful for liver diseases. We evaluated the usefulness of zinc (NPC-02; acetate formulation) supplementation. We conducted two NPC-02 studies on zinc-deficient patients (serum zinc < 70 μg/dL). Study 1: double-blind, randomized, placebo-controlled t  ...[more]

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