Ontology highlight
ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC7150837 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Tian Yu Y Bhide Yoshita C YC Woerdenbag Herman J HJ Huckriede Anke L W ALW Frijlink Henderik W HW Hinrichs Wouter L J WLJ Visser J Carolina JC
Pharmaceutics 20200308 3
Most influenza vaccines are administered via injection, which is considered as user-unfriendly. Vaccination via oral cavity using an orodispersible film (ODF) might be a promising alternative. To maintain the antigenicity of the vaccine during preparation and subsequent storage of these ODFs, sugars such as trehalose and pullulan can be employed as stabilizing excipients for the antigens. In this study, first, β-galactosidase was used as a model antigen. Solutions containing β-galactosidase and ...[more]