Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.
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ABSTRACT:
SUBMITTER: Roberts C
PROVIDER: S-EPMC7151129 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.
Journal of developmental biology 20200305 1
This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis in these processes by regulating availability of RA for receptor binding and signalling. Cyp26 enzymes are necessary to generate RA gradients and to protect specific tissues from RA signalling. Disruption of RA homeostasis leads to a wide variet ...[more]
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