Surface Chemistry-Dependent Evolution of the Nanomaterial Corona on TiO₂ Nanomaterials Following Uptake and Sub-Cellular Localization.

ABSTRACT: Nanomaterial (NM) surface chemistry has an established and significant effect on interactions at the nano-bio interface, with important toxicological consequences for manufactured NMs, as well as potent effects on the pharmacokinetics and efficacy of nano-therapies. In this work, the effects of different surface modifications (PVP, Dispex AA4040, and Pluronic F127) on the uptake, cellular distribution, and degradation of titanium dioxide NMs (TiO₂ NMs, ~10 nm core size) are assessed and correlated with the localization of fluorescently-labeled serum proteins forming their coronas. Imaging approaches with an increasing spatial resolution, including automated high throughput live cell imaging, correlative confocal fluorescence and reflectance microscopy, and dSTORM super-resolutio

SUBMITTER: Khan AO 

PROVIDER: S-EPMC7152854 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature