Unknown

Dataset Information

0

Boron Accumulation in Brain Tumor Cells through Boc-Protected Tryptophan as a Carrier for Boron Neutron Capture Therapy.


ABSTRACT: Boron neutron capture therapy (BNCT) is a binary therapeutic approach. Nonradioactive boron-10 atoms accumulated in tumor cells combining with the neutron beams produce two highly energetic particles that could eradicate the cell that takes it and the neighboring cells. Small molecules that carry boron atom, e.g. 5- and 6-boronated and 2,7-diboronated tryptophans, were assessed for their boron accumulation in U87-MG, LN229, and 3T3 for BNCT. TriBoc tryptophan, TB-6-BT, shows boron-10 at 300 ppm in both types of tumor cells with a tumor to normal ratio (T/N) of 5.19-5.25 (4 h). TB-5-BT and DBA-5-BT show boron-10 at 300 ppm (2 h) in U87-MG cells. TB-5-BT exerts a T/N of >9.66 (1 h) in LN229 compared with the current clinical boronophenyl alanine with a highest T/N of 2.3 (1 h) and accumulation concentration of <50 ppm. TB-5-BT and TB-6-BT warrant further animal study.

SUBMITTER: Chio CM 

PROVIDER: S-EPMC7153283 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9575175 | biostudies-literature
| S-EPMC8324832 | biostudies-literature
| S-EPMC4945594 | biostudies-literature
| S-EPMC8762747 | biostudies-literature
| S-EPMC10748186 | biostudies-literature
| S-EPMC10267362 | biostudies-literature
| S-EPMC9009440 | biostudies-literature
| S-EPMC5069687 | biostudies-literature
| S-EPMC7494062 | biostudies-literature
| S-EPMC9601095 | biostudies-literature