Ontology highlight
ABSTRACT:
SUBMITTER: Elje E
PROVIDER: S-EPMC7153628 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Elje Elisabeth E Mariussen Espen E Moriones Oscar H OH Bastús Neus G NG Puntes Victor V Kohl Yvonne Y Dusinska Maria M Rundén-Pran Elise E
Nanomaterials (Basel, Switzerland) 20200318 3
(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures better than 2D cultures. This study aims to compare cytotoxic and genotoxic responses induced by titanium dioxide (TiO<sub>2</sub>), silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) in 2D monolayer and 3D spheroid cultures of HepG2 human liver cells. (2) NPs were characterize ...[more]