Ontology highlight
ABSTRACT:
SUBMITTER: Zhou F
PROVIDER: S-EPMC7153896 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhou Fang F Schaffer Sophia A SA Schreiber Christoph C Segerer Felix J FJ Goychuk Andriy A Frey Erwin E Rädler Joachim O JO
PloS one 20200413 4
Cell migration on microlanes represents a suitable and simple platform for the exploration of the molecular mechanisms underlying cell cytoskeleton dynamics. Here, we report on the quasi-periodic movement of cells confined in stripe-shaped microlanes. We observe persistent polarized cell shapes and directed pole-to-pole motion within the microlanes. Cells depolarize at one end of a given microlane, followed by delayed repolarization towards the opposite end. We analyze cell motility via the spat ...[more]