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An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes.

ABSTRACT: The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) are recognized as inducing increased proliferation, cell cycle progression, invasion, and metastasis of cancer cells, which makes this class of transcripts a viable biomarker for cancer development and aggressiveness. Through our literature research, we also found that silencing of SNHGs through small interfering RNAs or short hairpin RNAs is very effective in both in vitro and in vivo experiments by lowering the aggressiveness of solid cancers. The knockdown of SNHG as a new cancer therapeutic option should be investigated more in the future.

SUBMITTER: Zimta AA

PROVIDER: S-EPMC7154078 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes.

Zimta Alina-Andreea AA Tigu Adrian Bogdan AB Braicu Cornelia C Stefan Cristina C Ionescu Calin C Berindan-Neagoe Ioana I

Frontiers in oncology 20200407

The small nucleolar RNA host genes (SNHGs) are a group of long non-coding RNAs, which are reported in many studies as being overexpressed in various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) are recognized as inducing increased proliferation, cell cycle progression, invasion, and metastasis of cancer cells, which makes this class of transcripts a viable biomarker for cancer development and aggressiveness. Through our literatu ...[more]

PMID: 32318335

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