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Indacaterol/glycopyrronium versus tiotropium or glycopyrronium in long-acting bronchodilator-naive COPD patients: A pooled analysis.

ABSTRACT:

Background and objective

Indacaterol/glycopyrronium (IND/GLY) 110/50??g once daily (q.d.) has demonstrated greater improvements in lung function, patient-reported outcomes and lower exacerbation rates versus mono long-acting muscarinic antagonists (LAMA) in chronic obstructive pulmonary disease (COPD) patients. However, data are limited on initial treatment with IND/GLY 110/50??g q.d. versus mono LAMA in COPD patients, not previously on maintenance treatment with long-acting bronchodilators (LABD).

Methods

A pooled analysis of ARISE, SHINE and SPARK trials was conducted to evaluate the efficacy of IND/GLY 110/50??g q.d. versus open-label (OL) tiotropium (TIO) 18??g q.d. and GLY 50??g q.d. in COPD patients, not on maintenance treatment with LABD at study entry (LABD-naïve). Efficacy was assessed after 24/26?weeks of treatment.

Results

In total, 998 LABD-naïve patients were included (IND/GLY: 353; OL TIO: 328; GLY: 317). Patients treated with IND/GLY 110/50??g q.d. experienced greater improvements in trough forced expiratory volume in 1 s (FEV₁ ) versus OL TIO 18??g q.d. (least squares mean treatment difference (?): 0.086?L) and GLY 50??g q.d. (?: 0.080?L) after 24/26?weeks. Improvements in electronic diary (eDiary) symptom scores, transition dyspnoea index (TDI) focal score, St George's Respiratory Questionnaire (SGRQ) total score and rescue medication use were also greater with IND/GLY versus OL TIO and GLY. Greater proportion of patients achieved minimal clinically important difference in trough FEV₁ , TDI and SGRQ with IND/GLY versus OL TIO and GLY.

Conclusion

LABD-naïve patients treated with IND/GLY 110/50??g q.d. achieved improvements in lung function, daily symptoms, dyspnoea, health-related quality of life and rescue medication use versus those who received single LAMA.

SUBMITTER: Muro S

PROVIDER: S-EPMC7155057 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Indacaterol/glycopyrronium versus tiotropium or glycopyrronium in long-acting bronchodilator-naïve COPD patients: A pooled analysis.

Muro Shigeo S Yoshisue Hajime H Kostikas Konstantinos K Olsson Petter P Gupta Pritam P Wedzicha Jadwiga A JA

Respirology (Carlton, Vic.) 20190724 4

<h4>Background and objective</h4>Indacaterol/glycopyrronium (IND/GLY) 110/50 μg once daily (q.d.) has demonstrated greater improvements in lung function, patient-reported outcomes and lower exacerbation rates versus mono long-acting muscarinic antagonists (LAMA) in chronic obstructive pulmonary disease (COPD) patients. However, data are limited on initial treatment with IND/GLY 110/50 μg q.d. versus mono LAMA in COPD patients, not previously on maintenance treatment with long-acting bronchodilat ...[more]

PMID: 31339215

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