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Cerebral oxygen metabolism in adults with sickle cell disease.


ABSTRACT: In sickle cell disease (SCD), oxygen delivery is impaired due to anemia, especially during times of increased metabolic demand, and cerebral blood flow (CBF) must increase to meet changing physiologic needs. But hyperemia limits cerebrovascular reserve (CVR) and ischemic risk prevails despite elevated CBF. The cerebral metabolic rate of oxygen (CMRO2 ) directly reflects oxygen supply and consumption and may therefore be more insightful than flow-based CVR measures for ischemic risk in SCD. We hypothesized that adults with SCD have impaired CMRO2 at rest and that a vasodilatory challenge with acetazolamide would improve CMRO2 . CMRO2 was calculated from CBF and oxygen extraction fraction (OEF), measured with arterial spin labeling and T2 -prepared tissue relaxation with inversion recovery (T2 -TRIR) MRI. We studied 36 adults with SCD without a clinical history of overt stroke, and nine healthy controls. As expected, CBF was higher in patients with SCD versus controls (mean?±?SD: 74?±?16 versus 46?±?5?mL/100?g/min, P?

SUBMITTER: Vaclavu L 

PROVIDER: S-EPMC7155077 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Cerebral oxygen metabolism in adults with sickle cell disease.

Václavů Lena L   Petr Jan J   Petersen Esben Thade ET   Mutsaerts Henri J M M HJMM   Majoie Charles B L CBL   Wood John C JC   VanBavel Ed E   Nederveen Aart J AJ   Biemond Bart J BJ  

American journal of hematology 20200128 4


In sickle cell disease (SCD), oxygen delivery is impaired due to anemia, especially during times of increased metabolic demand, and cerebral blood flow (CBF) must increase to meet changing physiologic needs. But hyperemia limits cerebrovascular reserve (CVR) and ischemic risk prevails despite elevated CBF. The cerebral metabolic rate of oxygen (CMRO<sub>2</sub> ) directly reflects oxygen supply and consumption and may therefore be more insightful than flow-based CVR measures for ischemic risk in  ...[more]

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