White matter microstructure in youth with and at risk for bipolar disorder.

ABSTRACT:

Objectives

Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum and fronto-limbic pathways. These abnormalities might constitute trait or state marker and have been suggested to result from aberrant maturation and to relate to difficulties in emotion regulation.

Methods

To determine whether WM alterations represent a trait, disease or resilience marker, we compared youth at risk for BD (n = 36 first-degree relatives, REL) to youth with BD (n = 36) and healthy volunteers (n = 36, HV) using diffusion tensor imaging.

Results

Individuals with BD and REL did not differ from each other in WM microstructure and, compared to HV, showed similar aberrations in the superior corona radiata (SCR)/

SUBMITTER: Linke JO 

PROVIDER: S-EPMC7155105 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature