Ontology highlight
ABSTRACT:
SUBMITTER: Gingell JJ
PROVIDER: S-EPMC7155191 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
ACS pharmacology & translational science 20200226 2
Calcitonin gene-related peptide (CGRP) is a neuropeptide that is involved in the transmission of pain. Drugs targeting CGRP or a CGRP receptor are efficacious in the treatment of migraine. The canonical CGRP receptor is a complex of a G protein-coupled receptor, the calcitonin-like receptor (CLR), with an accessory protein, receptor activity-modifying protein 1 (RAMP1). A second receptor, the AMY<sub>1</sub> receptor, a complex of the calcitonin receptor with RAMP1, is a dual high-affinity recep ...[more]