Reverse-genetics studies of lncRNAs-what we have learnt and paths forward.
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ABSTRACT:
SUBMITTER: Gao F
PROVIDER: S-EPMC7155256 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Reverse-genetics studies of lncRNAs-what we have learnt and paths forward.
Gao Fan F Cai Ye Y Kapranov Philipp P Xu Dongyang D
Genome biology 20200414 1
Long non-coding RNAs (lncRNAs) represent a major fraction of the transcriptome in multicellular organisms. Although a handful of well-studied lncRNAs are broadly recognized as biologically meaningful, the fraction of such transcripts out of the entire collection of lncRNAs remains a subject of vigorous debate. Here we review the evidence for and against biological functionalities of lncRNAs and attempt to arrive at potential modes of lncRNA functionality that would reconcile the contradictory co ...[more]
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