Ontology highlight
ABSTRACT:
SUBMITTER: Jones MG
PROVIDER: S-EPMC7155257 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Jones Matthew G MG Khodaverdian Alex A Quinn Jeffrey J JJ Chan Michelle M MM Hussmann Jeffrey A JA Wang Robert R Xu Chenling C Weissman Jonathan S JS Yosef Nir N
Genome biology 20200414 1
The pairing of CRISPR/Cas9-based gene editing with massively parallel single-cell readouts now enables large-scale lineage tracing. However, the rapid growth in complexity of data from these assays has outpaced our ability to accurately infer phylogenetic relationships. First, we introduce Cassiopeia-a suite of scalable maximum parsimony approaches for tree reconstruction. Second, we provide a simulation framework for evaluating algorithms and exploring lineage tracer design principles. Finally, ...[more]