Association between rs2107595 HDAC9 gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort.

ABSTRACT: BACKGROUND:Histone deacetylase 9 (HDAC9) plays an important role in transcriptional regulation, cell cycle progression and developmental events; moreover, it has been investigated as a candidate gene in a number of conditions, including the onset and progression of atherosclerosis. We hypothesized that the rs2107595 HDAC9 gene polymorphism may be associated with advanced carotid artery disease in a Slovenian cohort. We also investigated the effect of this polymorphism on HDAC9 receptor expression in the internal carotid artery (ICA) specimens obtained by endarterectomy. METHODS:This case-control study enrolled 619 unrelated Slovenian patients: 311 patients with ICA stenosis >?75% as the study group and 308 patients with ICA stenosis ?75%, and the numerical areal density of HDAC9 positive cells was calculated. RESULTS:The occurrence of advanced ICA atherosclerosis in the Slovenian cohort was 3.81 times higher in the codominant genetic model (OR?=?3.81, 95%CI?=?1.06-13.77, p?=?0.04), and 3.10 times higher in the recessive genetic model (OR?=?3.10, 95%CI?=?1.16-8.27, p?=?0.02). In addition, the A allele of rs2107595 was associated with increased HDAC9 expression in the ICA specimens obtained by endarterectomy. CONCLUSIONS:We observed a significant association between the AA genotype of rs2107595 with the advanced carotid artery disease in our Slovenian cohort, indicating that this polymorphism may be a genetic risk factor for ICA atherosclerosis.

SUBMITTER: Grbic E 

PROVIDER: S-EPMC7155263 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature