Ontology highlight
ABSTRACT:
SUBMITTER: Karakashev S
PROVIDER: S-EPMC7155421 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Karakashev Sergey S Fukumoto Takeshi T Zhao Bo B Lin Jianhuang J Wu Shuai S Fatkhutdinov Nail N Park Pyoung-Hwa PH Semenova Galina G Jean Stephanie S Cadungog Mark G MG Borowsky Mark E ME Kossenkov Andrew V AV Liu Qin Q Zhang Rugang R
Cancer cell 20200130 2
In response to DNA double-strand breaks, MAD2L2-containing shieldin complex plays a critical role in the choice between homologous recombination (HR) and non-homologous end-joining (NHEJ)-mediated repair. Here we show that EZH2 inhibition upregulates MAD2L2 and sensitizes HR-proficient epithelial ovarian cancer (EOC) to poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor in a CARM1-dependent manner. CARM1 promotes MAD2L2 silencing by driving the switch from the SWI/SNF complex to EZH2 ...[more]