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Biology and Biochemistry of Bacterial Proteasomes.

ABSTRACT: Proteasomes are a class of protease that carry out the degradation of a specific set of cellular proteins. While essential for eukaryotic life, proteasomes are found only in a small subset of bacterial species. In this chapter, we present the current knowledge of bacterial proteasomes, detailing the structural features and catalytic activities required to achieve proteasomal proteolysis. We describe the known mechanisms by which substrates are doomed for degradation, and highlight potential non-degradative roles for components of bacterial proteasome systems. Additionally, we highlight several pathways of microbial physiology that rely on proteasome activity. Lastly, we explain the various gaps in our understanding of bacterial proteasome function and emphasize several opportunities for further study.

SUBMITTER: Becker SH

PROVIDER: S-EPMC7155931 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Biology and Biochemistry of Bacterial Proteasomes.

Becker Samuel H SH Li Huilin H Li Huilin H Heran Darwin K K

Sub-cellular biochemistry 20190101

Proteasomes are a class of protease that carry out the degradation of a specific set of cellular proteins. While essential for eukaryotic life, proteasomes are found only in a small subset of bacterial species. In this chapter, we present the current knowledge of bacterial proteasomes, detailing the structural features and catalytic activities required to achieve proteasomal proteolysis. We describe the known mechanisms by which substrates are doomed for degradation, and highlight potential non- ...[more]

PMID: 31939157

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