Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC7156269 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Yang Xiao X Zhao Lian L Campos Maria M MM Abu-Asab Mones M Ortolan Davide D Hotaling Nathan N Bharti Kapil K Wong Wai T WT
eLife 20200401
The choroid, which provides vascular supply to the outer retina, demonstrates progressive degeneration in aging and age-related macular degeneration (AMD). However mechanisms that maintain or compromise choroidal homeostasis are obscure. We discovered that the ablation of choroidal macrophages via CSF1R blockade was associated with choroidal vascular atrophy and retinal pigment epithelial (RPE) changes including structural disruption, downregulation of visual cycle genes, and altered angiogenic ...[more]