Ontology highlight
ABSTRACT:
SUBMITTER: Gallardo A
PROVIDER: S-EPMC7156284 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Gallardo Amador A Molina Aldara A Asenjo Helena G HG Martorell-Marugán Jordi J Montes Rosa R Ramos-Mejia Verónica V Sanchez-Pozo Antonio A Carmona-Sáez Pedro P Lopez-Onieva Lourdes L Landeira David D
Life science alliance 20200413 5
Mammals optimize their physiology to the light-dark cycle by synchronization of the master circadian clock in the brain with peripheral clocks in the rest of the tissues of the body. Circadian oscillations rely on a negative feedback loop exerted by the molecular clock that is composed by transcriptional activators Bmal1 and Clock, and their negative regulators Period and Cryptochrome. Components of the molecular clock are expressed during early development, but onset of robust circadian oscilla ...[more]