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Screening of copper and palladium-mediated reactions compatible with DNA-encoded chemical libraries.

ABSTRACT: The construction of DNA-encoded chemical libraries (DECLs) crucially relies on the availability of chemical reactions, which are DNA-compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, we present our optimization and validation procedures for three copper and palladium-catalyzed reactions (Suzuki cross-coupling, Sonogashira cross-coupling and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC)), which have been successfully used by our group for the construction of large encoded libraries.

SUBMITTER: Nicholas F

PROVIDER: S-EPMC7156289 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Screening of copper and palladium-mediated reactions compatible with DNA-encoded chemical libraries.

Favalli Nicholas N Bassi Gabriele G Zanetti Tania T Scheuermann Jörg J Neri Dario D

Helvetica chimica acta 20190401 4

The construction of DNA-encoded chemical libraries (DECLs) crucially relies on the availability of chemical reactions, which are DNA-compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, we present our optimization and validation procedures for three copper and palladium-catalyzed reactions (Suzuki cross-coupling, Sonogashira cross-coupling and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC)), which have been successfully used by our gr ...[more]

PMID: 32292208

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