Ontology highlight
ABSTRACT:
SUBMITTER: Lee YD
PROVIDER: S-EPMC7156411 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lee Yong Deok YD Kim Bongjun B Jung Suhan S Kim Haemin H Kim Min Kyung MK Kwon Jun-Oh JO Song Min-Kyoung MK Lee Zang Hee ZH Kim Hong-Hee HH
Experimental & molecular medicine 20200324 3
Osteoclasts (OCs), cells specialized for bone resorption, are generated from monocyte/macrophage precursors by a differentiation process governed by RANKL. Here, we show that DCTN1, a key component of the dynactin complex, plays important roles in OC differentiation. The expression of DCTN1 was upregulated by RANKL. The inhibition of DCTN1 expression by gene knockdown suppressed OC formation, bone resorption, and the induction of NFATc1 and c-Fos, critical transcription factors for osteoclastoge ...[more]