Ontology highlight
ABSTRACT:
SUBMITTER: Dijkman K
PROVIDER: S-EPMC7156429 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Dijkman Karin K Lubbers Rosalie R Borggreven Nicole V NV Ottenhoff Tom H M THM Joosten Simone A SA Trouw Leendert A LA Verreck Frank A W FAW
Scientific reports 20200414 1
Tuberculosis (TB) causes 1.6 million deaths annually. Early differential diagnosis of active TB infection is essential in optimizing treatment and reducing TB mortality, but is hampered by a lack of accurate and accessible diagnostics. Previously, we reported on complement component C1q, measured in serum by ELISA, as a candidate biomarker for active tuberculosis. In this work we further examine the dynamics of C1q as a marker of progressive TB disease in non-human primates (NHP). We assessed sy ...[more]