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Human Papilloma Virus Increases ?Np63? Expression in Head and Neck Squamous Cell Carcinoma.


ABSTRACT: P63, and in particular the most expressed ?Np63? isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ?Np63? and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ?Np63? is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ?Np63? mRNA and protein levels.

SUBMITTER: Citro S 

PROVIDER: S-EPMC7156594 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma.

Citro Simona S   Bellini Alice A   Medda Alessandro A   Sabatini Maria Elisa ME   Tagliabue Marta M   Chu Francesco F   Chiocca Susanna S  

Frontiers in cellular and infection microbiology 20200408


P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-posit  ...[more]

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