Dataset Information

Brain Morphometry Estimation: From Hours to Seconds Using Deep Learning.

ABSTRACT: Motivation: Brain morphometry from magnetic resonance imaging (MRI) is a promising neuroimaging biomarker for the non-invasive diagnosis and monitoring of neurodegenerative and neurological disorders. Current tools for brain morphometry often come with a high computational burden, making them hard to use in clinical routine, where time is often an issue. We propose a deep learning-based approach to predict the volumes of anatomically delineated subcortical regions of interest (ROI), and mean thicknesses and curvatures of cortical parcellations directly from T1-weighted MRI. Advantages are the timely availability of results while maintaining a clinically relevant accuracy. Materials and Methods: An anonymized dataset of 574 subjects (443 healthy controls and 131 patients with epilepsy) was used for the supervised training of a convolutional neural network (CNN). A silver-standard ground truth was generated with FreeSurfer 6.0. Results: The CNN predicts a total of 165 morphometric measures directly from raw MR images. Analysis of the results using intraclass correlation coefficients showed, in general, good correlation with FreeSurfer generated ground truth data, with some of the regions nearly reaching human inter-rater performance (ICC > 0.75). Cortical thicknesses predicted by the CNN showed cross-sectional annual age-related gray matter atrophy rates both globally (thickness change of -0.004 mm/year) and regionally in agreement with the literature. A statistical test to dichotomize patients with epilepsy from healthy controls revealed similar effect sizes for structures affecting all subtypes as reported in a large-scale epilepsy study. Conclusions: We demonstrate the general feasibility of using deep learning to estimate human brain morphometry directly from T1-weighted MRI within seconds. A comparison of the results to other publications shows accuracies of comparable magnitudes for the subcortical volumes and cortical thicknesses.

SUBMITTER: Rebsamen M

PROVIDER: S-EPMC7156625 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Brain Morphometry Estimation: From Hours to Seconds Using Deep Learning.

Rebsamen Michael M Suter Yannick Y Wiest Roland R Reyes Mauricio M Rummel Christian C

Frontiers in neurology 20200408

<b>Motivation:</b> Brain morphometry from magnetic resonance imaging (MRI) is a promising neuroimaging biomarker for the non-invasive diagnosis and monitoring of neurodegenerative and neurological disorders. Current tools for brain morphometry often come with a high computational burden, making them hard to use in clinical routine, where time is often an issue. We propose a deep learning-based approach to predict the volumes of anatomically delineated subcortical regions of interest (ROI), and m ...[more]

PMID: 32322235

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Project description:ObjectivesMultiple b-value gas diffusion-weighted MRI (DW-MRI) enables non-invasive and quantitative assessment of lung morphometry, but its long acquisition time is not well-tolerated by patients. We aimed to accelerate multiple b-value gas DW-MRI for lung morphometry using deep learning.MethodsA deep cascade of residual dense network (DC-RDN) was developed to reconstruct high-quality DW images from highly undersampled k-space data. Hyperpolarized 129Xe lung ventilation images were acquired from 101 participants and were retrospectively collected to generate synthetic DW-MRI data to train the DC-RDN. Afterwards, the performance of the DC-RDN was evaluated on retrospectively and prospectively undersampled multiple b-value 129Xe MRI datasets.ResultsEach slice with size of 64 × 64 × 5 could be reconstructed within 7.2 ms. For the retrospective test data, the DC-RDN showed significant improvement on all quantitative metrics compared with the conventional reconstruction methods (p < 0.05). The apparent diffusion coefficient (ADC) and morphometry parameters were not significantly different between the fully sampled and DC-RDN reconstructed images (p > 0.05). For the prospectively accelerated acquisition, the required breath-holding time was reduced from 17.8 to 4.7 s with an acceleration factor of 4. Meanwhile, the prospectively reconstructed results showed good agreement with the fully sampled images, with a mean difference of -0.72% and -0.74% regarding global mean ADC and mean linear intercept (Lm) values.ConclusionsDC-RDN is effective in accelerating multiple b-value gas DW-MRI while maintaining accurate estimation of lung microstructural morphometry, facilitating the clinical potential of studying lung diseases with hyperpolarized DW-MRI.Key points• The deep cascade of residual dense network allowed fast and high-quality reconstruction of multiple b-value gas diffusion-weighted MRI at an acceleration factor of 4. • The apparent diffusion coefficient and morphometry parameters were not significantly different between the fully sampled images and the reconstructed results (p > 0.05). • The required breath-holding time was reduced from 17.8 to 4.7 s and each slice with size of 64 × 64 × 5 could be reconstructed within 7.2 ms.

Dataset Information

Brain Morphometry Estimation: From Hours to Seconds Using Deep Learning.

Publications

Brain Morphometry Estimation: From Hours to Seconds Using Deep Learning.

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